Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation

Wenmin Deng, Zhongjin Yang, Yue Hu, +3

Free Radical Biology and Medicine

InflammationRheumatologyAnti-inflammatoryAutoimmune DiseaseImmunology +9

Syntheses and Biological Evaluation of Costunolide, Parthenolide, and Their Fluorinated Analogues

Zhongjin Yang, Weizhi Ge, Qiuying Li, +7

Journal of Medicinal Chemistry

Bioorganic ChemistryTheir Fluorinated AnaloguesOrganic ChemistryChemistryPharmaceutical Chemistry +17

Total Syntheses of Parthenolide and Its Analogues with Macrocyclic Stereocontrol

Jing Long, Shanfeng Zhang, Panpan Wang, +4

Journal of Medicinal Chemistry

Combinatorial ChemistryBioorganic ChemistryOrganic ChemistryChemistryHeterocycle Chemistry +15

Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation

Yue Hu, Zhongjin Yang, Yitao Ou, +7

International Immunopharmacology

InflammationAnti-inflammatoryMitochondrial DamageAutoimmune DiseaseLipid Peroxidation +10

Discovery of Highly Potent Pinanamine-Based Inhibitors against Amantadine- and Oseltamivir-Resistant Influenza A Viruses

Xin Zhao, Runfeng Li, Yang Zhou, +3

Journal of Medicinal Chemistry

Artemisinin-derived artemisitene blocks ROS-mediated NLRP3 inflammasome and alleviates ulcerative colitis

Lei Hua, Shuli Liang, Yinghua Zhou, +11

International Immunopharmacology

InflammationAnti-inflammatoryImmunologyChronic InflammationPathology +3

Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities

Cheng Zhang, Yue Hu, Ping Sun, +9

European Journal of Medicinal Chemistry

InflammationAnti-inflammatoryMedicinePotent Anti-inflammation ActivitiesImmunology +6

Synthesis and biological evaluation of dithiocarbamate esters of parthenolide as potential anti-acute myelogenous leukaemia agents

Yahui Ding, Zhongjin Yang, Weizhi Ge, +5

Journal of Enzyme Inhibition and Medicinal Chemistry

Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives

Zhongjin Yang, Bei-Jia Kuang, Kang Ning, +7

European Journal of Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)HeterocyclicNatural SciencesMedicine +6

Bortezomib inhibits NLRP3 inflammasome activation and NF-κB pathway to reduce psoriatic inflammation

Xiuhui Chen, Yanhong Chen, Yitao Ou, +9

Biochemical Pharmacology

InflammationPsoriatic InflammationAnti-inflammatoryMedicineImmunology +12