Steve De Vos

Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases

Luc Van Rompaey, René Galien, Ellen M. van der Aar et al. · The Journal of Immunology · 2013 · 225 citations · Full text

Immunology, Immunologic Mechanism, Immune Dysregulation +19

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

Mathieu Pizzonero, Sonia Dupont, Marielle Babel et al. · Journal of Medicinal Chemistry · 2014 · 107 citations · Full text

Inflammation, From Hit, Medicinal Chemistry +15

The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis

Tobias Puengel, Steve De Vos, Jana Hundertmark et al. · Journal of Clinical Medicine · 2020 · 77 citations · Full text

Liver Fibrosis, Immunology, Pathology +20

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84

Zobaer Al Mahmud, Laura Jenkins, Trond Ulven et al. · Scientific Reports · 2017 · 46 citations · Full text

Discovery of 9-Cyclopropylethynyl-2-((<i>S</i>)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-<i>a</i>]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial

Frédéric Labéguère, Sonia Dupont, Luke J. Alvey et al. · Journal of Medicinal Chemistry · 2020 · 42 citations · Full text