Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

Oliver Krenkel, Tobias Puengel, Olivier Govaere, +13

Hepatology

Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury

Jana C. Mossanen, Oliver Krenkel, Can Ergen, +13

Hepatology

Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages☆

Sander Lefere, Tobias Puengel, Jana Hundertmark, +12

Journal of Hepatology

InflammationMolecular PharmacologyPan-ppar AgonistsHepatologyExperimental Steatohepatitis +9

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

Oliver Krenkel, Jana Hundertmark, Ali T. Abdallah, +9

Gut

Acquisition of epithelial plasticity in human chronic liver disease

Christopher Gribben, Vasileios Galanakis, Alexander Calderwood, +16

Nature

The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis

Tobias Puengel, Steve De Vos, Jana Hundertmark, +13

Journal of Clinical Medicine

Liver FibrosisImmunologyPathologyFatty Liver DiseaseMcfa Receptor Gpr84 +18

Differential impact of the dual CCR2/CCR5 inhibitor cenicriviroc on migration of monocyte and lymphocyte subsets in acute liver injury

Tobias Puengel, Oliver Krenkel, Marlene Kohlhepp, +4

PLoS ONE

ImmunologyPathologyImmunologic MechanismImmunotherapyInflammation +19

Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis

Tobias Puengel, Sander Lefere, Jana Hundertmark, +13

International Journal of Molecular Sciences

ImmunologyFgf21 Analogue SynergizesPathologyFatty Liver DiseaseInflammation +21

Association of Serum Calprotectin Concentrations with Mortality in Critically Ill and Septic Patients

Theresa H. Wirtz, Lukas Buendgens, Ralf Weiskirchen, +14

Diagnostics

Dissecting Acute Drug‐Induced Hepatotoxicity and Therapeutic Responses of Steatotic Liver Disease Using Primary Mouse Liver and Blood Cells in a Liver‐On‐A‐Chip Model

Hanyang Liu, Yin Guo, Marlene Kohlhepp, +9

Advanced Science

Liver FibrosisImmunologyLiver‐on‐a‐chip ModelCell InjuryFatty Liver Disease +23