Liver inflammation abrogates immunological tolerance induced by Kupffer cells

Felix Heymann, Julia Peusquens, Isis Ludwig‐Portugall, +12

Hepatology

Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury

Jana C. Mossanen, Oliver Krenkel, Can Ergen, +13

Hepatology

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

Eva Van Overmeire, Benoı̂t Stijlemans, Felix Heymann, +12

Cancer Research

ImmunologyBiological MicroenvironmentsImmunologic MechanismCell ProliferationImmunotherapy +15

DestVI identifies continuums of cell types in spatial transcriptomics data

Romain Lopez, Baoguo Li, Hadas Keren‐Shaul, +14

Nature Biotechnology

Functional GenomicsDestvi Identifies ContinuumsEngineeringSingle Cell SequencingMedicine +10

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

Leonie Brockmann, Shiwa Soukou, Babett Steglich, +25

Nature Communications

The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers

Matthias Bartneck, Peter L. Schrammen, Diana Möckel, +11

Cellular and Molecular Gastroenterology and Hepatology

Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles

Can Ergen, Felix Heymann, Wa’el Al Rawashdeh, +12

Biomaterials

Cell-based Drug DeliveryNanomedicineDrug TargetingEngineeringPolymer-drug Conjugate +6

Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span

Joshua I. Gray, Daniel P. Caron, Steven B. Wells, +18

Science Immunology

Lymphocyte DevelopmentAdaptive Immune SystemImmunologyImmune RegulationImmunodominance +21

Single-cell multiomic analysis of thymocyte development reveals drivers of CD4+ T cell and CD8+ T cell lineage commitment

Zoë Steier, Dominik A. Aylard, Laura L. McIntyre, +8

Nature Immunology

Deep generative modeling of sample-level heterogeneity in single-cell genomics

Pierre Boyeau, Justin Hong, Adam Gayoso, +6

EngineeringGeneticsGenomicsMolecular CompositionSingle Cell Sequencing +15