Karin Pike‐Overzet

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

Steven J. Howe, Marc R. Mansour, Kerstin Schwarzwaelder et al. · Journal of Clinical Investigation · 2008 · 1.3K citations · Full text

Medicine, Genetics, Oncology +13

Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

Irene Homminga, Rob Pieters, Anton W. Langerak et al. · Cancer Cell · 2011 · 382 citations · Full text

Medicine, Molecular Genetics, Oncology +14

New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling

Willem A. Dik, Karin Pike‐Overzet, Floor Weerkamp et al. · The Journal of Experimental Medicine · 2005 · 325 citations · Full text

Life Sciences, Developmental Biology, Molecular Biology +17

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

Annette Deichmann, Salima Hacein‐Bey‐Abina, Manfred Schmidt et al. · Journal of Clinical Investigation · 2007 · 258 citations · Full text

Life Sciences, Cell Biology, Genetics +13

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

Kerstin Schwarzwaelder, Steven J. Howe, Manfred Schmidt et al. · Journal of Clinical Investigation · 2007 · 204 citations · Full text

Life Sciences, Genetics, Immunology +13