Steven J. Howe

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

Steven J. Howe, Marc R. Mansour, Kerstin Schwarzwaelder et al. · Journal of Clinical Investigation · 2008 · 1.3K citations · Full text

Medicine, Genetics, Oncology +13

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

H. Bobby Gaspar, Kathryn L. Parsley, Steven J. Howe et al. · The Lancet · 2004 · 684 citations

Medicine, Immunology, Molecular Genetics +17

Effective gene therapy with nonintegrating lentiviral vectors

Rafael J. Yáñez‐Muñoz, Kamaljit S. Balaggan, Angus MacNeil et al. · Nature Medicine · 2006 · 460 citations

Pharmacy, Biotechnology, Molecular Biology +14

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

Annette Deichmann, Salima Hacein‐Bey‐Abina, Manfred Schmidt et al. · Journal of Clinical Investigation · 2007 · 258 citations · Full text

Life Sciences, Cell Biology, Genetics +13

Long-Term Persistence of a Polyclonal T Cell Repertoire After Gene Therapy for X-Linked Severe Combined Immunodeficiency

H. Bobby Gaspar, Samantha Cooray, Kimberly Gilmour et al. · Science Translational Medicine · 2011 · 233 citations · Full text

Medicine, Hematology, Immunology +15