Kerstin Schwarzwaelder

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

Steven J. Howe, Marc R. Mansour, Kerstin Schwarzwaelder et al. · Journal of Clinical Investigation · 2008 · 1.3K citations · Full text

Medicine, Genetics, Oncology +13

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1

Marion Ott, Manfred Schmidt, Kerstin Schwarzwaelder et al. · Nature Medicine · 2006 · 1.2K citations

Life Sciences, Immunology, Molecular Medicine +10

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

Stefan Stein, Marion Ott, Stephan Schultze‐Strasser et al. · Nature Medicine · 2010 · 784 citations

Medicine, Genetics, Molecular Genetics +16

High-resolution insertion-site analysis by linear amplification–mediated PCR (LAM-PCR)

Manfred Schmidt, Kerstin Schwarzwaelder, Cynthia C. Bartholomae et al. · Nature Methods · 2007 · 334 citations

Life Sciences, Molecular Biology, Molecular Genetics +7

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

Annette Deichmann, Salima Hacein‐Bey‐Abina, Manfred Schmidt et al. · Journal of Clinical Investigation · 2007 · 258 citations · Full text

Life Sciences, Cell Biology, Genetics +13