MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

Scott A. Armstrong, Jane Staunton, Lewis B. Silverman, +7

Nature Genetics

Hematological MalignancyChromatinDistinct Gene ExpressionMixed-phenotype Acute LeukemiaGenetics +10

A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

Monique L. den Boer, Marjon van Slegtenhorst, Renée X. de Menezes, +12

The Lancet Oncology

Hematological MalignancyPoor Treatment OutcomePediatric HematologyMedicineGenome-wide Classification Study +10

<i>FBW7</i> mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

Jennifer O’Neil, Jonathan Grim, Peter R. Strack, +11

The Journal of Experimental Medicine

A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial

Rob Pieters, Martin Schrappe, Paola De Lorenzo, +17

The Lancet

Hematological MalignancyAcute Lymphoblastic LeukaemiaOncologyPediatric EpidemiologyPediatric Hematology +5

Gene-Expression Patterns in Drug-Resistant Acute Lymphoblastic Leukemia Cells and Response to Treatment

Amy de Haar-Holleman, Meyling Cheok, Monique L. den Boer, +10

New England Journal of Medicine

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

Guo Wei, David Twomey, Justin Lamb, +9

Cancer Cell

Natural SciencesMolecular BiologyResistance Mutation (Virology)Pathway AnalysisGlucocorticoid Resistance +6

Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study

Brian V. Balgobind, Susana C. Raimondi, Jochen Harbott, +31

Blood

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

Priscila Pini Zenatti, Daniel Ribeiro, Wenqing Li, +19

Nature Genetics

Hematological MalignancyMixed-phenotype Acute LeukemiaImmunologyHematologyPathology +3

Biological and therapeutic aspects of infant leukemia

Andrea Biondi, Giuseppe Cimino, Rob Pieters, +1

Blood

Inhibition of FLT3 in MLL

Scott A. Armstrong, Andrew L. Kung, Meghann E. Mabon, +10

Cancer Cell

Molecular PharmacologyMolecular RegulationMedicineMechanism Of ActionPharmacology +3