Darshan S. Sappal

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Marc L. Hyer, Michael A. Milhollen, Jeff Ciavarri et al. · Nature Medicine · 2018 · 414 citations

Medicine, Anti-cancer Agent, Small-molecule Inhibitor +8

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

Christopher Blackburn, Kenneth M. Gigstad, Paul Hales et al. · Biochemical Journal · 2010 · 144 citations · Full text

Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib

Siquan Chen, Jonathan L. Blank, Theodore Peters et al. · Cancer Research · 2010 · 103 citations · Full text

Genome-wide Sirna Screen, Proteasome Inhibition Induces, Medicine +14

Biological characterization of MLN944: A potent DNA binding agent

Darshan S. Sappal, A. Kathleen McClendon, James Fleming et al. · Molecular Cancer Therapeutics · 2004 · 52 citations · Full text

Chemoprevention Strategy, Molecular Biology, Cancer Biology +16

Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways

Khristofer Garcia, Jonathan L. Blank, David C. Bouck et al. · Molecular Cancer Therapeutics · 2014 · 50 citations · Full text

Chromatin, Genome Instability, Replication Forks +13