James Fleming

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

Christine Bulawa, Stephen Connelly, Michael J. DeVit et al. · Proceedings of the National Academy of Sciences · 2012 · 728 citations · Full text

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

Zhijian Li, Franco J. Vizeacoumar, Sondra Bahr et al. · Nature Biotechnology · 2011 · 434 citations · Full text

Systematic Exploration, Natural Sciences, Genetics +7

Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341

James Fleming, Eric S. Lightcap, Seth Sadis et al. · Proceedings of the National Academy of Sciences · 2002 · 199 citations · Full text

Proteomic Technology, Proteasome Inhibition, Protein Function +15

Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines

Xiaohu Ouyang, Evgueni L. Piatnitski, Vatee Pattaropong et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 98 citations

Medicinal Chemistry, Polymer-drug Conjugate, Medicine +11

Synthesis and structure–activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors

Xiaohu Ouyang, Xiaoling Chen, Evgueni L. Piatnitski et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 69 citations

Medicinal Chemistry, Medicine, Natural Sciences +8