John Wityak

Discovery of <i>N</i>-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Louis J. Lombardo, Francis Y. Lee, Ping Chen et al. · Journal of Medicinal Chemistry · 2004 · 1.3K citations · Full text

Drug Target, Preclinical Assays, Pharmacotherapy +19

MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

John V. Duncia, Joseph B. Santella, C. Anne Higley et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 404 citations · Full text

Biological Activity, Mek Inhibitors, Medicinal Chemistry +12

2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of <i>N</i> -(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent <i>pan</i> -Src Kinase Inhibitor

Jagabandhu Das, Ping Chen, Derek Norris et al. · Journal of Medicinal Chemistry · 2006 · 393 citations · Full text

Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation

Tai-An Lin, Kim W. McIntyre, Jagabandhu Das et al. · Biochemistry · 2004 · 111 citations · Full text

Inflammatory Lung Disease, Lung Inflammation, T-regulatory Cell +21

Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56lck inhibitors

Jagabandhu Das, Robert V. Moquin, James C. Lin et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 105 citations · Full text

Potent P56lck Inhibitors, Medicinal Chemistry, Biochemistry +8