Louisa Dal Cengio

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

Amber L. Southwell, Amy Smith-Dijak, Chris Kay et al. · Human Molecular Genetics · 2016 · 136 citations · Full text

Neurogenomics, Genetics, Molecular Biology +22

Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease

Amber L. Southwell, Holly Kordasiewicz, Douglas R. Langbehn et al. · Science Translational Medicine · 2018 · 122 citations

Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease

Nicholas S. Caron, Amber L. Southwell, Cynthia Brouwers et al. · Nucleic Acids Research · 2019 · 73 citations · Full text

BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep

Daniela Rojo, Louisa Dal Cengio, Anna Badner et al. · Neuron · 2023 · 39 citations · Full text

Sleep Disorders, Bmal1 Loss, Neurological Progress +6

A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

Amber L. Southwell, Niels H. Skotte, Erika B. Villanueva et al. · Human Molecular Genetics · 2017 · 36 citations · Full text

Knockout Mouse, Neurodegenerative Diseases, Transgenic Mouse Models +13