Nicholas S. Caron

Kinase inhibitors modulate huntingtin cell localization and toxicity

Randy Singh Atwal, Carly R. Desmond, Nicholas S. Caron et al. · Nature Chemical Biology · 2011 · 243 citations

Signaling Pathway, Medicine, Receptor Tyrosine Kinase +5

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin

Nicholas S. Caron, Carly R. Desmond, Jianrun Xia et al. · Proceedings of the National Academy of Sciences · 2013 · 147 citations · Full text

Molecular Regulation, Genetics, Polyglutamine Domain Flexibility +16

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease

Lise N. Munsie, Nicholas S. Caron, Randy Singh Atwal et al. · Human Molecular Genetics · 2011 · 133 citations · Full text

Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease

Amber L. Southwell, Holly Kordasiewicz, Douglas R. Langbehn et al. · Science Translational Medicine · 2018 · 122 citations

Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease

Costanza Ferrari Bardile, Marta Garcia‐Miralles, Nicholas S. Caron et al. · Proceedings of the National Academy of Sciences · 2019 · 118 citations · Full text

White Matter, Genetics, White Matter Abnormalities +17