Cynthia Brouwers

AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington’s Disease Minipig Model

Melvin M. Evers, Jana Miniarikova, Štefan Juhás et al. · Molecular Therapy · 2018 · 157 citations · Full text

AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington’s disease

Jana Miniarikova, Virginie Zimmer, Raygene Martier et al. · Gene Therapy · 2017 · 100 citations · Full text

Genetics, Rat Model, Mutant Huntingtin Aggregation +18

AAV5-miHTT Gene Therapy Demonstrates Sustained Huntingtin Lowering and Functional Improvement in Huntington Disease Mouse Models

Elisabeth A Spronck, Cynthia Brouwers, Astrid Vallès et al. · Molecular Therapy — Methods & Clinical Development · 2019 · 85 citations · Full text

Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease

Nicholas S. Caron, Amber L. Southwell, Cynthia Brouwers et al. · Nucleic Acids Research · 2019 · 73 citations · Full text

AAV5-miHTT Lowers Huntingtin mRNA and Protein without Off-Target Effects in Patient-Derived Neuronal Cultures and Astrocytes

Sonay Keskin, Cynthia Brouwers, Marina Sogorb-González et al. · Molecular Therapy — Methods & Clinical Development · 2019 · 69 citations · Full text