Andy Watt

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

Clotilde Lagier‐Tourenne, Magdalini Polymenidou, Kasey R. Hutt et al. · Nature Neuroscience · 2012 · 750 citations

Life Sciences, Molecular Biology, Neuroscience +10

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Michael T. Lam, Han Cho, Hanna P. Lesch et al. · Nature · 2013 · 551 citations

Life Sciences, Genetics, Molecular Biology +12

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron et al. · Neuron · 2016 · 540 citations · Full text

Life Sciences, Genetics, Molecular Genetics +15

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

Shuling Guo, Carla Casu, Sara Gardenghi et al. · Journal of Clinical Investigation · 2013 · 215 citations · Full text

Medicine, Hematology, Molecular Medicine +17

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

Sebastien A. Burel, Christopher E. Hart, Patrick Cauntay et al. · Nucleic Acids Research · 2015 · 200 citations · Full text

Life Sciences, Molecular Biology, Toxicology +16