Sebastien A. Burel

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

Youzhong Yuan, Liming Zhou, Toshihiro Miyamoto et al. · Proceedings of the National Academy of Sciences · 2001 · 430 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

Sebastien A. Burel, Christopher E. Hart, Patrick Cauntay et al. · Nucleic Acids Research · 2015 · 200 citations · Full text

Life Sciences, Molecular Biology, Toxicology +16

Dichotomy of AML1-ETO Functions: Growth Arrest versus Block of Differentiation

Sebastien A. Burel, Nari Harakawa, Liming Zhou et al. · Molecular and Cellular Biology · 2001 · 142 citations · Full text

Life Sciences, Hematology, Molecular Biology +12

Comprehensive Structure–Activity Relationship of Triantennary<i>N</i>-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes

Thazha P. Prakash, Jinghua Yu, Michael T. Migawa et al. · Journal of Medicinal Chemistry · 2016 · 131 citations

Pharmacy, Pharmaceutics, Pharmacology +12

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

Brooke A. Anderson, Graeme C. Freestone, Audrey Low et al. · Nucleic Acids Research · 2021 · 131 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17