Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Sara Gardenghi, Maria Franca Marongiu, Pedro Luiz Ramos, +15

Blood

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

Pedro Luiz Ramos, Carla Casu, Sara Gardenghi, +13

Nature Medicine

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

Sara Gardenghi, Pedro Luiz Ramos, Maria Franca Marongiu, +16

Journal of Clinical Investigation

Iron MetabolismExcessive Iron AbsorptionIron DeficiencyRedox BiologyOxidative Stress +18

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

Shuling Guo, Carla Casu, Sara Gardenghi, +7

Journal of Clinical Investigation

Mouse Tmprss6Iron MetabolismImmune RegulationTmprss6 Ameliorates HemochromatosisImmune System +20

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia

Rajasekhar N.V.S. Suragani, Sharon M Cawley, Robert Li, +8

Blood

Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus

Sara Gardenghi, Tom M. Renaud, Alessandra Meloni, +7

Blood

Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia

Erik R. Anderson, Matthew Taylor, Xiang Xue, +7

Proceedings of the National Academy of Sciences

Therapeutic Hemoglobin Levels after Gene Transfer in β-Thalassemia Mice and in Hematopoietic Cells of β-Thalassemia and Sickle Cells Disease Patients

Laura Breda, Carla Casu, Sara Gardenghi, +15

PLoS ONE

ImmunohematologyImmunologyImmune RegulationBlood CellImmune System +15

-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload

Luca Melchiori, Sara Gardenghi, Stefano Rivella

Advances in Hematology

Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt

Chang Yeob Han, Ja Hyun Koo, Sung Hoon Kim, +5

Nature Communications