Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Sara Gardenghi, Maria Franca Marongiu, Pedro Luiz Ramos, +15

Blood

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

Pedro Luiz Ramos, Carla Casu, Sara Gardenghi, +13

Nature Medicine

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

Sara Gardenghi, Pedro Luiz Ramos, Maria Franca Marongiu, +16

Journal of Clinical Investigation

Iron MetabolismExcessive Iron AbsorptionIron DeficiencyRedox BiologyOxidative Stress +18

Klf1 Affects DNase II-Alpha Expression in the Central Macrophage of a Fetal Liver Erythroblastic Island: a Non-Cell-Autonomous Role in Definitive Erythropoiesis

Susanna Porcu, Maria Francesca Manchinu, Maria Franca Marongiu, +9

Molecular and Cellular Biology

Dnase2a Ko MiceGeneticsBlood CellCentral MacrophageHematology +14

In vivo activation of the human  -globin gene: the therapeutic potential in  -thalassemic mice

Maria Francesca Manchinu, Maria Franca Marongiu, Daniela Poddie, +8

Haematologica

Therapeutic PotentialImmunologyImmune RegulationBlood CellHeme Trafficking +15

Reversible Disruption of Pre-Pulse Inhibition in Hypomorphic-Inducible and Reversible CB1-/- Mice

Maria Franca Marongiu, Daniela Poddie, Susanna Porcu, +8

PLoS ONE

Activation of the δ-Globin Gene by the β-Globin Gene CACCC Motif

Maria Serafina Ristaldi, Stefania Casula, Susanna Porcu, +3

Blood Cells Molecules and Diseases

Protein FunctionSignal TransductionMolecular PhysiologyMolecular Regulationδ-Globin Gene +4

Beta-Globin Gene Cluster Haplotypes in the Corsican and Sardinian Populations

Veronica Latini, Giuseppe Vona, Maria Serafina Ristaldi, +4

Human Biology

Induction of therapeutic levels of HbF in genome‐edited primary β⁰39‐thalassaemia haematopoietic stem and progenitor cells

Maura Mingoia, Cristian Antonio Caria, Lin Ye, +12

British Journal of Haematology

Differentiation of single cell derived human mesenchymal stem cells into cells with a neuronal phenotype: RNA and microRNA expression profile

Francesca Crobu, Veronica Latini, Maria Franca Marongiu, +8

Molecular Biology Reports

Regenerative MedicineNeuronal PhenotypeDevelopmental BiologyMedicineAdult Stem Cell +10