Concepedia

Author

Jeffrey Clarine

Amgen (United States)ORCID

Also Known As

Clarine, Jeffrey, J. Clarine, Jeffrey Clarine, Jeffrey G. Clarine

23

Publications

155

Citations

5

H-Index

24

Concepts

All Affiliations

Amgen (United States)
JC

About

Jeffrey Clarine is an author at Amgen (United States) specializing in medicine, drug discovery, and pharmacology.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

5

5

152

2

Biochemistry

3

3

70

3

Natural Sciences

1

1

18

4

Cell Biology

1

1

22

5

Immunology

1

1

60

Jeffrey Clarine

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5

Publications

152

Citations

5

H-Index

YearCitations

Discovery of TRPM8 Antagonist (<i>S</i>)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

Daniel B. Horne, Kaustav Biswas, James Brown,

Journal of Medicinal Chemistry

2018

60

Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

Daniel B. Horne, Nuria Tamayo, Michael D. Bartberger,

Journal of Medicinal Chemistry

2014

42

The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading

Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos,

Molecular Cancer Therapeutics

2024

22

Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility

Robert M. Rzasa, Michael Frohn, Kristin L. Andrews,

Bioorganic & Medicinal Chemistry

2014

18

The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core

Paul E. Harrington, David J. St. Jean, Jeffrey Clarine,

Bioorganic & Medicinal Chemistry Letters

2010

10

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