Francesca Deflorian

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Active since

2003

Affiliations

National Institute of Diabetes and Digestive and Kidney Diseases(Current)

National Institutes of Health

Heptares Therapeutics (United Kingdom)

University of Padua

University of Trieste

Francesca Deflorian is an author at National Institute of Diabetes and Digestive and Kidney Diseases specializing in pharmacology, medicinal chemistry, and ligand binding.

ORCID

Publications per year

2003–2025

Publications

Intracellular allosteric antagonism of the CCR9 receptor

Christine Oswald, Mathieu Rappas, James Kean et al. · Nature · 2016 · 278 citations

Life Sciences, Biochemistry, Molecular Biology +13

Structures of Human A 1 and A 2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity

R.K. Cheng, Elena Segala, N.J. Robertson et al. · Structure · 2017 · 221 citations · Full text

Medicine, Biochemistry, Pharmacology +12

Controlling the Dissociation of Ligands from the Adenosine A 2A Receptor through Modulation of Salt Bridge Strength

Elena Segala, Dong Guo, R.K. Cheng et al. · Journal of Medicinal Chemistry · 2016 · 192 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +17

Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

Jian‐kang Jiang, Kamran Ghoreschi, Francesca Deflorian et al. · Journal of Medicinal Chemistry · 2008 · 125 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

High end GPCR design: crafted ligand design and druggability analysis using protein structure, lipophilic hotspots and explicit water networks

Jonathan S. Mason, Andrea Bortolato, Dahlia R. Weiss et al. · In Silico Pharmacology · 2013 · 86 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

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