Francesca Deflorian

Intracellular allosteric antagonism of the CCR9 receptor

Christine Oswald, Mathieu Rappas, James Kean et al. · Nature · 2016 · 270 citations

Inflammation, Signal Transduction, G Protein-coupled Receptor +7

Structures of Human A 1 and A 2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity

R.K. Cheng, Elena Segala, N.J. Robertson et al. · Structure · 2017 · 216 citations · Full text

Human A 1, Molecular Physiology, Signal Transduction +9

Controlling the Dissociation of Ligands from the Adenosine A _2A Receptor through Modulation of Salt Bridge Strength

Elena Segala, Dong Guo, R.K. Cheng et al. · Journal of Medicinal Chemistry · 2016 · 189 citations · Full text

Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3<i>R</i>,4<i>R</i>)-4-methyl-3-(methyl(7H-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

Jian‐kang Jiang, Kamran Ghoreschi, Francesca Deflorian et al. · Journal of Medicinal Chemistry · 2008 · 124 citations · Full text

Compounds Selectivity, Heterocycle Chemistry, Chemical Biology +21

High end GPCR design: crafted ligand design and druggability analysis using protein structure, lipophilic hotspots and explicit water networks

Jonathan S. Mason, Andrea Bortolato, Dahlia R. Weiss et al. · In Silico Pharmacology · 2013 · 86 citations · Full text

Chemical Biology, Medicinal Chemistry, Explicit Water Networks +13