Emily Rychak

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Antonia Lopez‐Girona, Derek Mendy, Takumi Ito et al. · Leukemia · 2012 · 798 citations · Full text

Medicine, Oncology, Pharmacology +15

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Philip P. Chamberlain, Antonia Lopez‐Girona, Karen Miller et al. · Nature Structural & Molecular Biology · 2014 · 515 citations

Medicine, Medicinal Chemistry, Pharmacology +5

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

Christine Surka, Liqing Jin, Nathan Mbong et al. · Blood · 2020 · 221 citations · Full text

Medicine, Cancer Biology, Molecular Biology +11

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Patrick R. Hagner, Hon‐Wah Man, Celia Fontanillo et al. · Blood · 2015 · 200 citations · Full text

Life Sciences, Molecular Biology, Oncology +14

Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity

Anita K. Gandhi, Derek Mendy, Michelle F. Waldman et al. · British Journal of Haematology · 2013 · 104 citations · Full text

Medicine, Oncology, Pharmacology +14