The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

Peter van Galen, Antonija Kreso, Nathan Mbong, +13

Nature

Developmental BiologyMedicineStem Cell MobilizationAdult Stem CellUnfolded Protein Response +5

TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding

Penka S. Petrova, Natasja Nielsen Viller, Mark Wong, +25

Clinical Cancer Research

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

Christine Surka, Liqing Jin, Nathan Mbong, +26

Blood

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia

Peter van Galen, Nathan Mbong, Antonia Kreso, +7

Cell Reports

AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody–Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML

Daniel S. Pereira, Claudia Guevara, Liqing Jin, +18

Molecular Cancer Therapeutics

ImmunologyImmunotherapeuticsImmunotherapyCancer BiologyTumor Biology +16

Reduced Lymphoid Lineage Priming Promotes Human Hematopoietic Stem Cell Expansion

Peter van Galen, Antonija Kreso, Erno Wienholds, +9

Cell stem cell

Lymphocyte DevelopmentMedicineStem Cell MobilizationHematologyImmunology +5

Minor Chemical Constituents of <i>Vitex Pinnata</i>

Athar Ata, Nathan Mbong, Chad D. Iverson, +1

Natural Product Communications

Food ChemistryVitex PinnataMedicinal ChemistryNew Iridoid GlucosideAntifungal Agent +11

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

Liberalis Debraj Boila, Subhadeep Ghosh, Subham K. Bandyopadhyay, +22

Leukemia

Hematological MalignancyChromatinGenome InstabilityMixed-phenotype Acute LeukemiaMolecular Biology +6

An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers

Weihsu C. Chen, Julie S. Yuan, Yan Xing, +15

Cancer Research

A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome

Héléna Boutzen, Seyed Ali Madani Tonekaboni, Michelle Chan‐Seng‐Yue, +12

Leukemia