Hon‐Wah Man

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

Peter Schäfer, Anastasia Parton, Lori Capone et al. · Cellular Signalling · 2014 · 306 citations · Full text

Medicine, Immunology, Pharmacology +17

A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos

Mary E. Matyskiela, Weihong Zhang, Hon‐Wah Man et al. · Journal of Medicinal Chemistry · 2017 · 291 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +13

The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

Ling Lu, Faribourz Payvandi, Lei Wu et al. · Microvascular Research · 2008 · 224 citations

Medicine, Oncology, Pharmacology +17

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Patrick R. Hagner, Hon‐Wah Man, Celia Fontanillo et al. · Blood · 2015 · 200 citations · Full text

Life Sciences, Molecular Biology, Oncology +14

Discovery of (<i>S</i>)-<i>N</i>-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1<i>H</i>-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Hon‐Wah Man, Peter Schäfer, Lu Min Wong et al. · Journal of Medicinal Chemistry · 2009 · 182 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14