Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

Peter Schäfer, Anastasia Parton, Lori Capone, +7

Cellular Signalling

A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos

Mary E. Matyskiela, Weihong Zhang, Hon‐Wah Man, +16

Journal of Medicinal Chemistry

The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

Ling Lu, Faribourz Payvandi, Lei Wu, +9

Microvascular Research

OncologyAngiogenesisAnti-cancer Drug LenalidomideMedicineEndothelial Cell Function +9

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Patrick R. Hagner, Hon‐Wah Man, Celia Fontanillo, +26

Blood

Discovery of (<i>S</i>)-<i>N</i>-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1<i>H</i>-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Hon‐Wah Man, Peter Schäfer, Lu Min Wong, +11

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryPharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +14

Enhancement of Cytokine Production and AP-1 Transcriptional Activity in T Cells by Thalidomide-Related Immunomodulatory Drugs

Peter Schäfer, Anita K. Gandhi, Michelle A. Loveland, +9

Journal of Pharmacology and Experimental Therapeutics

Asymmetric Synthesis of Stegobinone via Boronic Ester Chemistry

Donald S. Matteson, Hon‐Wah Man, O. C. HO

Journal of the American Chemical Society

Chiral CentersBioorganic ChemistryEngineeringBiochemistryNatural Sciences +12

Protein Degradation via CRL4^CRBN Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1

Joshua D. Hansen, Kevin R. Condroski, Matthew Correa, +14

Journal of Medicinal Chemistry

Drug TargetProtein AssemblyMolecular BiologyChemical BiologyCereblon Modulator 3 +17

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Alexander L. Ruchelman, Hon‐Wah Man, Weihong Zhang, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesIsosteric Analogs +7

Hydrolysis of Substituted 1,3,2-Dioxaborolanes and an Asymmetric Synthesis of a Differentially Protected <i>syn</i>,<i>syn</i>-3-Methyl-2,4-hexanediol

Donald S. Matteson, Hon‐Wah Man

The Journal of Organic Chemistry

Derivative (Chemistry)EngineeringSubstituted 1,3,2-DioxaborolanesDifferentially Protected SynAsymmetric Synthesis +8