Cedric Poinsard

Discovery and Optimization of Selective Na _v 1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

Sharan K. Bagal, Peter J. Bungay, Stephen M. Denton et al. · ACS Medicinal Chemistry Letters · 2015 · 41 citations · Full text

Medicine, Neuroscience, Pharmacology +17

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics

David J. Rawson, Stephen A. Ballard, Chris Barber et al. · Bioorganic & Medicinal Chemistry · 2011 · 28 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12

In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists

Simon J. Mantell, Karl R. Gibson, Simon A. Osborne et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 17 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen and oxygen linked derivatives of pyrido[3,4-d]pyrimidin-4-ylamines

Gareth W. Harbottle, N. Feeder, Karl R. Gibson et al. · Tetrahedron Letters · 2007 · 12 citations

Pharmacy, Chemistry, Medicinal Chemistry +9