Stephen M. Denton

Discovery of Clinical Candidate 4-[2-(5-Amino-1<i>H</i>-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-<i>N</i>-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na_V1.7

Nigel A. Swain, D. V. Batchelor, Serge Beaudoin et al. · Journal of Medicinal Chemistry · 2017 · 82 citations · Full text

Discovery and Optimization of Selective Na _v 1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

Sharan K. Bagal, Peter J. Bungay, Stephen M. Denton et al. · ACS Medicinal Chemistry Letters · 2015 · 40 citations · Full text

A Modified Bouveault Reaction for the Preparation of α,α-Dimethylamines from Amides

Stephen M. Denton · Synlett · 1999 · 36 citations

Engineering, Organic Chemistry, Chemistry +5

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics

David J. Rawson, Stephen A. Ballard, Chris Barber et al. · Bioorganic & Medicinal Chemistry · 2011 · 28 citations · Full text

Dose-proportional Pharmacokinetics, Oral Bioavailability, Pharmaceutical Science +9