The discovery of long acting β2-adrenoreceptor agonists

Alan D. Brown, Mark E. Bunnage, Paul A. Glossop, +9

Bioorganic & Medicinal Chemistry Letters

Molecular Pharmacologyβ2-Adrenoreceptor AgonistsMedicinePhysiologyNeuropeptide Receptor +6

The ring contraction of δ-lactones with leaving group α-substituents: a strategy for the synthesis of 2,5-disubstituted highly functionalised homochiral tetrahydrofurans

Sik-man S. Choi, Paul M. Myerscough, Antony J. Fairbanks, +7

Journal of the Chemical Society Chemical Communications

Group α-SubstituentsEngineeringBiochemistryFunctionalised Homochiral TetrahydrofuransExcellent Yield +10

3-Hydroxymuscarines from L-Rhamnose

Simon J. Mantell, Peter S. Ford, David J. Watkin, +2

Tetrahedron

Medicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesStereoselective Synthesis +3

The discovery of adamantyl-derived, inhaled, long acting β2-adrenoreceptor agonists

Alan D. Brown, Mark E. Bunnage, Paul A. Glossop, +9

Bioorganic & Medicinal Chemistry Letters

Molecular Pharmacologyβ2-Adrenoreceptor AgonistsMedicinePhysiologyPulmonary Pharmacology +6

The discovery of indole-derived long acting β2-adrenoceptor agonists for the treatment of asthma and COPD

Alan D. Brown, Mark E. Bunnage, Paul A. Glossop, +8

Bioorganic & Medicinal Chemistry Letters

AsthmaAnti-inflammatoryMedicinePhysiologyPulmonary Pharmacology +3

Dearomatizing Disrotatory Electrocyclic Ring Closure of Lithiated N-Benzoyloxazolidines

Jonathan Clayden, Savroop Purewal, Madeleine Helliwell, +1

Angewandte Chemie International Edition

SAR of a series of inhaled A2A agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data

Simon J. Mantell, Peter T. Stephenson, Sandra M. Monaghan, +14

Bioorganic & Medicinal Chemistry Letters

Inhaled A2a AgonistsMedicinePulmonary PharmacologyClinical PharmacologyClinical Pharmacokinetic Data +7

Design and application of locally delivered agonists of the adenosine A_2Areceptor

Simon J. Mantell, Rhys Jones, Mike Trevethick

Expert Review of Clinical Pharmacology

Inflammatory Lung DiseaseImmunologyPharmacotherapyExperimental PharmacologyInflammation +19

Inhaled adenosine A2A receptor agonists for the treatment of chronic obstructive pulmonary disease

Simon J. Mantell, Peter T. Stephenson, Sandra M. Monaghan, +15

Bioorganic & Medicinal Chemistry Letters

Advanced Lung DiseaseMedicinePulmonary PharmacologyPulmonary MedicinePharmacotherapy +4

A practical synthesis of (+)-muscarine from L-rhamnose

Simon J. Mantell, George W. J. Fleet, David Brown

Journal of the Chemical Society Perkin Transactions 1

Practical SynthesisBioorganic ChemistryEngineeringNatural SciencesDiversity-oriented Synthesis +10