Concepedia

In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists

Simon J. Mantell, Karl R. Gibson, Simon A. Osborne, Graham N. Maw, H. Rees, Peter G. Dodd, Ben S. Greener, Gareth W. Harbottle, William A. Million, Cedric Poinsard,

Bioorganic & Medicinal Chemistry Letters · 2009 · 17 citations · 5 references

DOIFull text

Open access

Concepts

References

5

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 626 citations

, , +17

Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-<i>d</i>]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors

S. KLUTCHKO, Hairong Zhou, R. Thomas Winters et al. · Journal of Medicinal Chemistry · 2006 · 79 citations · Full text

, , +16

Structure–activity relationships of novel non-competitive mGluR1 antagonists: A potential treatment for chronic pain

Dafydd R. Owen, Peter G. Dodd, Simon Gayton et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 21 citations · Full text

, , +14

Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists

Guo Zhu Zheng, Pramila Bhatia, Teodozyj Kolasa et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 21 citations · Full text

, , +16

Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen and oxygen linked derivatives of pyrido[3,4-d]pyrimidin-4-ylamines

Gareth W. Harbottle, N. Feeder, Karl R. Gibson et al. · Tetrahedron Letters · 2007 · 12 citations

, , +9