Eugene Amparo

Discovery of 1-[3-(Aminomethyl)phenyl]-<i>N</i>-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1<i>H</i>-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Donald Pinto, Michael J. Orwat, Shuaige Wang et al. · Journal of Medicinal Chemistry · 2001 · 172 citations · Full text

Medicine, Pharmacology, Drug Discovery +11

1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa

Donald Pinto, Michael J. Orwat, Mimi L. Quan et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 63 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

The discovery and structure–activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase

Matthew G. LaPorte, Tandy L. Draper, Lori E. Miller et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 34 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

A Noncleavable Retro-Binding Peptide That Spans the Substrate Binding Cleft of Serine Proteases. Atomic Structure of Nazumamide A:  Human Thrombin

V. Nienaber, Eugene Amparo · Journal of the American Chemical Society · 1996 · 21 citations

Life Sciences, Biochemistry, Medicinal Chemistry +15

Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase

Matthew G. LaPorte, T.A. Lessen, Lara K. Leister et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 12 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13