Matthew G. LaPorte

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-κB Activation, and Is Active in Patient-Derived Xenograft Models

Christopher A. Benetatos, Yasuhiro Mitsuuchi, Jennifer M. Burns et al. · Molecular Cancer Therapeutics · 2014 · 175 citations

Life Sciences, Oncology, Pharmacology +17

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

Stephen M. Condon, Yasuhiro Mitsuuchi, Yijun Deng et al. · Journal of Medicinal Chemistry · 2014 · 151 citations

Medicine, Oncology, Pharmacology +13

Total Syntheses of the <i>Securinega</i> Alkaloids (+)-14,15-Dihydronorsecurinine, (−)-Norsecurinine, and Phyllanthine

Gyoonhee Han, Matthew G. LaPorte, James J. Folmer et al. · The Journal of Organic Chemistry · 2000 · 98 citations

Pharmacy, Chemistry, Medicinal Chemistry +12

Exploratory Synthetic Studies of the α-Methoxylation of Amides <i>via</i> Cuprous Ion-Promoted Decomposition of <i>o</i>-Diazobenzamides

Gyoonhee Han, Matthew G. LaPorte, Mathias C. McIntosh et al. · The Journal of Organic Chemistry · 1996 · 91 citations

Natural Sciences, Chemistry, Medicinal Chemistry +13

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

Donna M. Huryn, Jeffrey L. Brodsky, Kay M. Brummond et al. · Proceedings of the National Academy of Sciences · 2011 · 74 citations

Pharmacy, Medicinal Chemistry, Oncology +15