Donna M. Huryn

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

Soojay Banerjee, Alberto Bartesaghi, Alan Merk et al. · Science · 2016 · 353 citations · Full text

Structure Property Relationships of Carboxylic Acid Isosteres

Pierrik Lassalas, Bryant Gay, Caroline Lasfargeas et al. · Journal of Medicinal Chemistry · 2016 · 271 citations

Combinatorial Chemistry, Bioorganic Chemistry, Organic Chemistry +17

Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer’s Disease

Robert Martone, Hua Zhou, Kevin Atchison et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 157 citations

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

Annette Chiang, Juan‐Carlos Valderramos, Raghavan Balachandran et al. · Bioorganic & Medicinal Chemistry · 2009 · 140 citations · Full text

Select Pyrimidinones, Biochemistry, Antiparasitic Agent +10

Optimization of a Higher Throughput Microsomal Stability Screening Assay for Profiling Drug Discovery Candidates

Li Di, Edward H. Kerns, Yan Hong et al. · SLAS DISCOVERY · 2003 · 135 citations · Full text