Christopher A. Benetatos

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

James E. Vince, W. Wei‐Lynn Wong, Nufail Khan et al. · Cell · 2007 · 1.1K citations · Full text

Life Sciences, Cell Biology, Immunology +14

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Kate E. Lawlor, Nufail Khan, Alison Mildenhall et al. · Nature Communications · 2015 · 641 citations · Full text

Life Sciences, Immunology, Pathology +17

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

James E. Vince, Diep Chau, Bernard A. Callus et al. · The Journal of Cell Biology · 2008 · 237 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-κB Activation, and Is Active in Patient-Derived Xenograft Models

Christopher A. Benetatos, Yasuhiro Mitsuuchi, Jennifer M. Burns et al. · Molecular Cancer Therapeutics · 2014 · 175 citations

Life Sciences, Oncology, Pharmacology +17

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

Stephen M. Condon, Yasuhiro Mitsuuchi, Yijun Deng et al. · Journal of Medicinal Chemistry · 2014 · 151 citations

Medicine, Oncology, Pharmacology +13