RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Kate E. Lawlor, Nufail Khan, Alison Mildenhall, +17

Nature Communications

Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

Guang‐Hui Xiao, Michael Jeffers, Alfonso Bellacosa, +3

Proceedings of the National Academy of Sciences

ApoptosisImmunologyHgf/met SignalingCell DeathPathology +18

Protein Kinase C Promotes Apoptosis in LNCaP Prostate Cancer Cells through Activation of p38 MAPK and Inhibition of the Akt Survival Pathway

Yuichi Tanaka, M. Veronica Gavrielides, Yasuhiro Mitsuuchi, +2

Journal of Biological Chemistry

Pkc IsozymesChemoprevention StrategyApoptosisCell DeathP38 Mapk +17

Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.

Takeshi Kawamoto, Yasuhiro Mitsuuchi, Katsumi Toda, +7

Proceedings of the National Academy of Sciences

Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival

Yasushi Fujio, Kun Guo, Toshiaki Mano, +3

Molecular and Cellular Biology

ApoptosisImmunologyCell DeathCell CycleCellular Physiology +15

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

Yasuhiro Mitsuuchi, Steven W. Johnson, Gonosuke Sonoda, +3

Oncogene

ChromatinSignal TransductionCell RegulationGenetic DisorderReceptor Tyrosine Kinase +10

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-κB Activation, and Is Active in Patient-Derived Xenograft Models

Christopher A. Benetatos, Yasuhiro Mitsuuchi, Jennifer M. Burns, +18

Molecular Cancer Therapeutics

Chemoprevention StrategyApoptosisImmunologyCell DeathTumor Biology +20

Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism

Takeshi Kawamoto, Yasuhiro Mitsuuchi, Taira Ohnishi, +11

Biochemical and Biophysical Research Communications

Adrenal GlandMolecular PhysiologyAldo-keto ReductaseBiochemistryMedicine +8

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

Stephen M. Condon, Yasuhiro Mitsuuchi, Yijun Deng, +26

Journal of Medicinal Chemistry

Surgical OncologySolid TumorsApoptosisImmunologyCell Death +18

The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel.

Yasuhiro Mitsuuchi, Steven W. Johnson, Muthu Selvakumaran, +3

PubMed

Chemoprevention StrategyCell DeathCell CycleA2780 CellsCancer Biology +16