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1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa

Donald Pinto, Michael J. Orwat, Mimi L. Quan, Qi Han, Robert A. Galemmo, Eugene Amparo, Brian L. Wells, Christopher D. Ellis, Ming He, Richard Alexander,

Bioorganic & Medicinal Chemistry Letters · 2006 · 63 citations · 17 references

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References

17

The selective inhibition of thrombin by peptides of boroarginine.

Charles A. Kettner, Lawrence J. Mersinger, Robert M. Knabb · Journal of Biological Chemistry · 1990 · 253 citations · Full text

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Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-<i>N</i>-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1<i>H</i>-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Mimi L. Quan, Patrick Y. S. Lam, Qi Han et al. · Journal of Medicinal Chemistry · 2004 · 189 citations · Full text

, , +12

Discovery of 1-[3-(Aminomethyl)phenyl]-<i>N</i>-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1<i>H</i>-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Donald Pinto, Michael J. Orwat, Shuaige Wang et al. · Journal of Medicinal Chemistry · 2001 · 172 citations · Full text

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The Importance of Enzyme Inhibition Kinetics for the Effect of Thrombin Inhibitors in a Rat Model of Arterial Thrombosis

Margareta Elg, David Gustafsson, Johanna Deinum · Thrombosis and Haemostasis · 1997 · 114 citations

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Structure-Based Design of Novel Guanidine/Benzamidine Mimics:  Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants

Patrick Y. S. Lam, Charles G. Clark, Renhua Li et al. · Journal of Medicinal Chemistry · 2003 · 96 citations · Full text

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