Brian L. Wells

Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-<i>N</i>- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1<i>H</i>-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

James R. Pruitt, Donald Pinto, Robert A. Galemmo et al. · Journal of Medicinal Chemistry · 2003 · 75 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa

Donald Pinto, Michael J. Orwat, Mimi L. Quan et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 63 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Structure–activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors

Jeffrey Varnes, Dean A. Wacker, Donald Pinto et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 37 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +14

Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties

Donald Pinto, Robert A. Galemmo, Mimi L. Quan et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 29 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

(N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors

Robert A. Galemmo, John M. Fevig, David J. Carini et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 15 citations

Medicine, Medicinal Chemistry, Pharmacology +11