PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

David G. McEwan, Doris Popovic, Andrea Gubaš, +13

Molecular Cell

Cell AutophagyMitophagyProtein FunctionSignal TransductionNatural Sciences +9

PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

Yoshiko Iwai, Seigo Terawaki, Masaya Ikegawa, +2

The Journal of Experimental Medicine

Effector PhaseT-regulatory CellViral ImmunityImmunologyPathology +20

IFN-α Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity

Seigo Terawaki, Shunsuke Chikuma, Shiro Shibayama, +4

The Journal of Immunology

Adaptive Immune SystemImmunologyImmune RegulationCell DeathImmunologic Mechanism +19

PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo

Shunsuke Chikuma, Seigo Terawaki, Tamon Hayashi, +5

The Journal of Immunology

T-regulatory CellImmunologyPd-1-mediated SuppressionImmunologic MechanismCd4 T Cell Responses +15

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, +26

Nature Cell Biology

InflammationLysosomal Damage ResponseRenal FunctionLc3 LipidationBiochemistry +12

Initiation of NALT Organogenesis Is Independent of the IL-7R, LTβR, and NIK Signaling Pathways but Requires the Id2 Gene and CD3−CD4+CD45+ Cells

Satoshi Fukuyama, Takachika Hiroi, Yoshifumi Yokota, +8

Immunity

CytokineSignal TransductionImmune Cell DevelopmentImmunologyImmune Regulation +10

Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells

Giovanna Clavarino, Nuno Cláudio, Alexandre Dalet, +9

Proceedings of the National Academy of Sciences

Innate Immune SystemImmunologyImmune RegulationSubunit Ppp1r15a/gadd34Innate Immunity +24

RUN and FYVE domain–containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4

Seigo Terawaki, Voahirana Camosseto, Francesca Prete, +17

The Journal of Cell Biology

MitophagyImmunologyCd4 T Cell ResponsesImmune SystemImmunotherapy +17

Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation

Till Wenger, Seigo Terawaki, Voahirana Camosseto, +9

Autophagy

MitophagyImmunologyProteasomeCell AutophagyProteasome Processing +17

Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses

Daisuke Oikawa, Yusuke Sato, Fumiaki Ohtake, +16

Communications Biology