PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

David G. McEwan, Doris Popovic, Andrea Gubaš, +13

Molecular Cell

Cell AutophagyMitophagyProtein FunctionSignal TransductionNatural Sciences +9

Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

Andrea KH Stavoe, Pallavi P. Gopal, Andrea Gubaš, +2

eLife

Minimized combinatorial CRISPR screens identify genetic interactions in autophagy

Valentina Diehl, Martin Wegner, Paolo Grumati, +12

Nucleic Acids Research

Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

Guang Lu, Juan Yi, Andrea Gubaš, +15

Autophagy

A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities

Musharraf Jelani, Hannah C. Dooley, Andrea Gubaš, +12

Brain

MitophagyFamily MembersGeneticsPathologyMolecular Genetics +18

Homozygous missense <i>WIPI2</i> variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course

Reza Maroofian, Andrea Gubaš, Rauan Kaiyrzhanov, +12

Brain Communications

Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia

Laura M. Meyer, Sebastian E. Koschade, Jonas B. Vischedyk, +9

Autophagy

The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways

Andrea Gubaš, Christina Karantanou, Doris Popovic, +6

FEBS Letters

Metabolic Rewiring Is Essential for AML Cell Survival to Overcome Autophagy Inhibition by Loss of ATG3

Fatima Baker, Ibrahim H. Polat, Khalil Abou‐El‐Ardat, +10

Cancers

MitophagyImmunologyCell DeathMetabolic RemodelingAml Cell Survival +16

WIPI2b recruitment to phagophores and ATG16L1 binding are regulated by ULK1 phosphorylation

Andrea Gubaš, Eleanor Attridge, Harold B.J. Jefferies, +8

EMBO Reports