High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, +10

Journal of the American Society of Nephrology

Familial gastrointestinal stromal tumor with hyperpigmentation: Association with a germline mutation of the c-kit gene

Hironobu Maeyama, Eiko Hidaka, Hiroyoshi Ota, +13

Gastroenterology

Gastrointestinal OncologyGenetic DisorderGeneticsGastroenterologyPathology +4

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, +26

Nature Cell Biology

InflammationLysosomal Damage ResponseRenal FunctionLc3 LipidationBiochemistry +12

Suppression of autophagic activity by Rubicon is a signature of aging

Shuhei Nakamura, Masaki Oba, Mari Suzuki, +23

Nature Communications

Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule

Takeshi Yamamoto, Yoshitsugu Takabatake, Tomonori Kimura, +12

Autophagy

MitophagyAgingCell DeathGreen Fluorescent ProteinKidney Proximal Tubule +22

Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules

Atsushi Takahashi, Yoshitsugu Takabatake, Tomonori Kimura, +11

Diabetes

MitophagyCytoskeletonCellular PhysiologyKidney Proximal TubulesCell Autophagy +18

Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes

Shinsuke Sakai, Takeshi Yamamoto, Yoshitsugu Takabatake, +12

Journal of the American Society of Nephrology

Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux

Takeshi Yamamoto, Yoshitsugu Takabatake, Satoshi Minami, +16

Autophagy

Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation

Satoshi Minami, Takeshi Yamamoto, Yoshitsugu Takabatake, +14

Autophagy

MitophagyCell DeathKidney Proximal TubuleObesityCell Autophagy +21

Recurrent attacks of vomiting, hypertension and psychotic depression: a syndrome of periodic catecholamine and prostaglandin discharge

Tamotu Sato, Noboru Igarashi, Satoshi Minami, +4

European Journal of Endocrinology

Psychotic DepressionPsychotropic MedicationPsychopharmacologyPharmacotherapyDopaminergic Inhibition +19