Vikram Malhi

Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies

Yuan Chen, Jin Y. Jin, Sophie Mukadam et al. · Biopharmaceutics & Drug Disposition · 2012 · 110 citations

Physiologically Based Pharmacokinetics, Pharmacokinetic Modeling, Preclinical Drug Evaluation +13

Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449)

Anthony M. Giannetti, Harvey Wong, Gerrit J.P. Dijkgraaf et al. · Journal of Medicinal Chemistry · 2011 · 73 citations · Full text

Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

Richard Graham, Cornelis E. C. A. Hop, Marie T. Borin et al. · British Journal of Clinical Pharmacology · 2012 · 58 citations · Full text

A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry

Richard Graham, Bert L. Lum, Glenn Morrison et al. · Drug Metabolism and Disposition · 2011 · 56 citations

A phase Ib trial of belvarafenib in combination with cobimetinib in patients with advanced solid tumors: Interim results of dose-escalation and patients with NRAS-mutant melanoma of dose-expansion.

Sang Joon Shin, Jeeyun Lee, Tae Min Kim et al. · Journal of Clinical Oncology · 2021 · 29 citations

Phase Ib Trial, Pharmacotherapy, Metronomic Therapy +17