Rajar M. Manoharan

siRNA Conjugates Carrying Sequentially Assembled Trivalent <i>N-</i>Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing <i>In Vivo</i> in Hepatocytes

Shigeo Matsuda, Kristofer Keiser, Jayaprakash K. Nair et al. · ACS Chemical Biology · 2015 · 213 citations

Pharmacy, Molecular Biology, Pharmacology +17

Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology <i>in vivo</i>

Hartmut Jahns, Nate Taneja, Jennifer L. S. Willoughby et al. · Nucleic Acids Research · 2021 · 86 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

4′-<i>C</i>-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing

Elise Malek-Adamian, Dale C. Guenther, Shigeo Matsuda et al. · Journal of the American Chemical Society · 2017 · 68 citations

Life Sciences, Biochemistry, Molecular Biology +17

Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-<i>C</i>-Methyl Pyrimidine-Modified Oligonucleotides

Alexander V. Kel’in, Ivan Zlatev, Joel M. Harp et al. · The Journal of Organic Chemistry · 2016 · 43 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Shorter Is Better: The α-(<scp>l</scp>)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

Shigeo Matsuda, Saikat Bala, Jen-Yu Liao et al. · Journal of the American Chemical Society · 2023 · 40 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +17