Elise Malek-Adamian

Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells

Amy E. Arnold, Elise Malek-Adamian, Phuong Uyen Le et al. · Molecular Therapy — Nucleic Acids · 2018 · 77 citations · Full text

Pharmacy, Molecular Biology, Oncology +17

4′-<i>C</i>-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing

Elise Malek-Adamian, Dale C. Guenther, Shigeo Matsuda et al. · Journal of the American Chemical Society · 2017 · 68 citations

Life Sciences, Biochemistry, Molecular Biology +17

Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity

Daniel O’Reilly, Zachary J. Kartje, Eman A. Ageely et al. · Nucleic Acids Research · 2018 · 64 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

Adjusting the Structure of 2′-Modified Nucleosides and Oligonucleotides via C4′-α-F or C4′-α-OMe Substitution: Synthesis and Conformational Analysis

Elise Malek-Adamian, Mihai Burai Patrascu, Sunit Kumar Jana et al. · The Journal of Organic Chemistry · 2018 · 46 citations

Natural Sciences, Biochemistry, Chemistry +17

Design and enhanced gene silencing activity of spherical 2′-fluoroarabinose nucleic acids (FANA-SNAs)

Hassan H. Fakih, Adam Katolik, Elise Malek-Adamian et al. · Chemical Science · 2021 · 35 citations · Full text

Pharmacy, Biotechnology, Molecular Pharmaceutics +17