Dale C. Guenther - Concepedia

Author

Dale C. Guenther

University of Idaho

Also Known As

Dale C Guenther, Dale C. Guenther, Dale Guenther, Dale C Guenther

Publications

936

Citations

H-Index

Concepts

All Affiliations

University of Idaho Alnylam Pharmaceuticals (United States)Vanderbilt University Kurukshetra University Biotechnology Institute

About

Dale C. Guenther is an author at University of Idaho specializing in molecular biology, biochemistry, and nucleic acid biochemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Biochemistry	7	7	215
2	Natural Sciences	6	6	186
3	Medicine	5	5	323
4	Biomolecular Engineering	3	3	103
5	Engineering	2	2	71

Dale C. Guenther

Publications

791

Citations

H-Index

Page 1

	Year	Citations
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates Kirk Brown, Jayaprakash K. Nair, Maja M. Janas, Nature Biotechnology Rnai TherapeuticsLiver PhysiologyGene DeliveryAntisense TherapyTherapeutics	2022	225
4′-<i>C</i>-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing Elise Malek-Adamian, Dale C. Guenther, Shigeo Matsuda, Journal of the American Chemical Society	2017	65
Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity Joel M. Harp, Dale C. Guenther, Anna Bisbe, Nucleic Acids Research β-U EpimerChemical ModificationMolecular BiologyChemical BiologyNucleic Acid Chemistry	2018	44
Pyrene-functionalized triazole-linked 2′-deoxyuridines—probes for discrimination of single nucleotide polymorphisms (SNPs) Michael E. Østergaard, Dale C. Guenther, Pawan Kumar, Chemical Communications	2010	42
Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease Pawan Kumar, Rohan Degaonkar, Dale C. Guenther, Nucleic Acids Research Chimeric SirnasEngineeringMolecular BiologyGene DeliveryBiosynthesis	2020	42
Shorter Is Better: The α-(<scp>l</scp>)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, Journal of the American Chemical Society	2023	37
Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA Sujay P. Sau, Andreas S. Madsen, Peter Podbevšek, The Journal of Organic Chemistry Original Invader LnasGeneticsDna AnalysisMolecular BiologyPeptide Science	2013	32
C5‐Functionalized DNA, LNA, and α‐<scp>L</scp>‐LNA: Positional Control of Polarity‐Sensitive Fluorophores Leads to Improved SNP‐Typing Michael E. Østergaard, Pawan Kumar, Bharat Baral, Chemistry - A European Journal	2011	32
Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid) Pawan Kumar, Michael E. Østergaard, Bharat Baral, The Journal of Organic Chemistry Bioorganic ChemistryMolecular BiologyChemical BiologyMedicinal ChemistryNucleic Acid Chemistry	2014	31
Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β-<i>C</i>-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects Dale C. Guenther, S. Mori, Shigeo Matsuda, Journal of the American Chemical Society	2022	30

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