Dale C. Guenther

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Kirk Brown, Jayaprakash K. Nair, Maja M. Janas et al. · Nature Biotechnology · 2022 · 225 citations · Full text

Rnai Therapeutics, Liver Physiology, Gene Delivery +5

4′-<i>C</i>-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing

Elise Malek-Adamian, Dale C. Guenther, Shigeo Matsuda et al. · Journal of the American Chemical Society · 2017 · 65 citations

Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

Joel M. Harp, Dale C. Guenther, Anna Bisbe et al. · Nucleic Acids Research · 2018 · 44 citations · Full text

β-U Epimer, Chemical Modification, Molecular Biology +17

Pyrene-functionalized triazole-linked 2′-deoxyuridines—probes for discrimination of single nucleotide polymorphisms (SNPs)

Michael E. Østergaard, Dale C. Guenther, Pawan Kumar et al. · Chemical Communications · 2010 · 42 citations

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease

Pawan Kumar, Rohan Degaonkar, Dale C. Guenther et al. · Nucleic Acids Research · 2020 · 42 citations · Full text

Chimeric Sirnas, Engineering, Molecular Biology +20