Daniel O’Reilly

Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity

Daniel O’Reilly, Zachary J. Kartje, Eman A. Ageely et al. · Nucleic Acids Research · 2018 · 64 citations · Full text

Chemical Modification, Molecular Biology, Ribose Sugars +18

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease

Daniel O’Reilly, Jillian Belgrad, Chantal Ferguson et al. · Molecular Therapy · 2023 · 49 citations · Full text

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

Vignesh Hariharan, Minwook Shin, Ching‐Wen Chang et al. · Proceedings of the National Academy of Sciences · 2023 · 46 citations · Full text

Lung Inflammation, Viral Pathogenesis, Immunology +19

Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat

Liande Li, Xiulong Shen, Zhongtian Liu et al. · Nucleic Acid Therapeutics · 2018 · 44 citations · Full text

Diverse Chemical Modifications, Frataxin Protein Expression, Molecular Biology +19

Rationally Designed Anti-CRISPR Nucleic Acid Inhibitors of CRISPR-Cas9

Christopher L. Barkau, Daniel O’Reilly, Kushal J. Rohilla et al. · Nucleic Acid Therapeutics · 2019 · 34 citations · Full text