Heike S. Grimm

Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin

Marcus O.W. Grimm, Heike S. Grimm, Andreas Jochem Pätzold et al. · Nature Cell Biology · 2005 · 447 citations

Life Sciences, Biochemistry, Neuroscience +12

Mechanism of the cleavage specificity of Alzheimer’s disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

Stefan F. Lichtenthaler, Rong Wang, Heike S. Grimm et al. · Proceedings of the National Academy of Sciences · 1999 · 233 citations

Life Sciences, Biochemistry, Molecular Biology +17

Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms

Marcus O.W. Grimm, Johanna Kuchenbecker, Sven Grösgen et al. · Journal of Biological Chemistry · 2011 · 215 citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +17

Plant Sterols the Better Cholesterol in Alzheimer's Disease? A Mechanistical Study

Verena K. Burg, Heike S. Grimm, Tatjana L. Rothhaar et al. · Journal of Neuroscience · 2013 · 130 citations · Full text

Life Sciences, Neuroscience, Nutritional Sciences +17

Independent Inhibition of Alzheimer Disease β- and γ-Secretase Cleavage by Lowered Cholesterol Levels

Marcus O.W. Grimm, Heike S. Grimm, Inge Tomic et al. · Journal of Biological Chemistry · 2008 · 123 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17