Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Vito Guagnano, Pascal Furet, Carsten Spanka, +14

Journal of Medicinal Chemistry

Pharmaceutical ChemistryTumor BiologyMedicinal ChemistrySignaling PathwayGenitourinary Cancer +17

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1

Joseph Schoepfer, Wolfgang Jahnke, Giuliano Berellini, +24

Journal of Medicinal Chemistry

Drug TargetMixed-phenotype Acute LeukemiaMolecular BiologyTumor BiologyMyeloid Neoplasia +14

Extended kinase profile and properties of the protein kinase inhibitor nilotinib

Paul W. Manley, Peter Drueckes, Gabriele Fendrich, +7

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Drug TargetMedicineReceptor Tyrosine KinaseExtended Kinase ProfileAnti-cancer Agent +6

A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients

Ralph Tiedt, Elisa Degenkolbe, Pascal Furet, +14

Cancer Research

Mixed-phenotype Acute LeukemiaCancer PatientsTumor BiologyDrug ResistanceHematological Malignancy +19

Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805

Fabienne Baffert, Catherine H. Régnier, Alain De Pover, +19

Molecular Cancer Therapeutics

PharmacotherapyExcellent SelectivityPharmaceutical ChemistryMyeloid NeoplasiaHematological Malignancy +18

Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases

Karima Bettayeb, Òscar M. Tirado, Séverine Marionneau‐Lambot, +14

Cancer Research

Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

Pablo D. García, John L. Langowski, Yingyun Wang, +31

Clinical Cancer Research

Type II Inhibitors Targeting CDK2

Leila T. Alexander, Henrik Möbitz, Peter Drueckes, +6

ACS Chemical Biology

Photometric Microtiter Assay of Inorganic Phosphate in the Presence of Acid-Labile Organic Phosphates

Peter Drueckes, Reinhard Schinzel, D. Palm

Analytical Biochemistry

PhotochemistryBiochemistryNatural SciencesBiomineralizationBioanalysis +7

A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.

James H. Wright, Peter Drueckes, Joseph L. Bartoe, +3

Molecular Biology of the Cell

Molecular PhysiologyDevelopmental BiologySignal TransductionSignaling PathwayCell Regulation +12