Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

David Lyden, Koichi Hattori, Sérgio Dias, +17

Nature Medicine

AngiogenesisMedicineStem Cell MobilizationHematopoietic Precursor CellsStem Cell Research +9

Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

Beate Heissig, Koichi Hattori, Sérgio Dias, +9

Cell

Progenitor CellsRegenerative MedicineDevelopmental BiologyMedicineStem Cell Mobilization +9

Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis

Scott T. Avecilla, Koichi Hattori, Beate Heissig, +16

Nature Medicine

ThrombopoiesisThrombosisHematopoietic ProgenitorsBone Marrow FailureStem Cell Mobilization +12

Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

Koichi Hattori, Sérgio Dias, Beate Heissig, +9

The Journal of Experimental Medicine

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

David Jin, Koji Shido, Hans‐Georg Kopp, +19

Nature Medicine

InflammationCytokineCell RegulationSdf-1 Induces RevascularizationCxcr4+ Hemangiocytes +8

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment

Koichi Hattori, Beate Heissig, Yan Wu, +14

Nature Medicine

Developmental BiologyVegfr1+ Stem CellsPlacental Growth FactorMedicineStem Cell Mobilization +9

Plasma elevation of stromal cell–derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells

Koichi Hattori, Beate Heissig, Kei Tashiro, +8

Blood

Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration

Sérgio Dias, Koichi Hattori, Zhenping Zhu, +11

Journal of Clinical Investigation

Hematological MalignancyCancer ResearchPrimary LeukemiasMedicineCertain Leukemias +11

Mobilization of Endothelial and Hematopoietic Stem and Progenitor Cells by Adenovector‐Mediated Elevation of Serum Levels of SDF‐1, VEGF, and Angiopoietin‐1

Malcolm A.S. Moore, Koichi Hattori, Beate Heissig, +4

Annals of the New York Academy of Sciences

Cell TherapyImmunologyBlood CellPathologyImmunotherapy +22

Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

Sérgio Dias, Koichi Hattori, Beate Heissig, +8

Proceedings of the National Academy of Sciences

Mixed-phenotype Acute LeukemiaAutocrine Vegf/ Vegfr-2ImmunologyParacrine Vegf/vegfr LoopsTumor Biology +16