Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

Beate Heissig, Koichi Hattori, Sérgio Dias, +9

Cell

Progenitor CellsRegenerative MedicineDevelopmental BiologyMedicineStem Cell Mobilization +9

Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis

Scott T. Avecilla, Koichi Hattori, Beate Heissig, +16

Nature Medicine

ThrombopoiesisThrombosisHematopoietic ProgenitorsBone Marrow FailureStem Cell Mobilization +12

Stromal-derived factor 1–induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases

William J. Lane, Sérgio Dias, Koichi Hattori, +6

Blood

A role for niches in hematopoietic cell development

Beate Heissig, Yuichi Ohki, Yayoi Sato, +3

Hematology

Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells

Hidekazu Nishikii, Koji Eto, Noriko Tamura, +7

The Journal of Experimental Medicine

Blood CellEfficacious PlateletsRegenerative MedicineThrombosisHematology +17

Infection of Endothelium With E1 ⁻ E4 ⁺ , but Not E1 ⁻ E4 ⁻ , Adenovirus Gene Transfer Vectors Enhances Leukocyte Adhesion and Migration by Modulation of ICAM-1, VCAM-1, CD34, and Chemokine Expression

Shahin Rafii, Sérgio Dias, Sarah Meeus, +6

Circulation Research

The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models

Yousef Salama, Andries Heida, Kazuaki Yokoyama, +3

Blood Advances

ImmunologyAngiogenic FactorsCancer BiologyTumor BiologyRefractory Mm +15

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells

Fumio Nakahara, Jiro Kitaura, Tomoyuki Uchida, +19

Blood

Anagrelide metabolite induces thrombocytopenia in mice by inhibiting megakaryocyte maturation without inducing platelet aggregation

William J. Lane, Koichi Hattori, Sérgio Dias, +6

Experimental Hematology

InflammationThrombosisThrombopoiesisBlood PlateletMedicine +13

A Metalloproteinase Inhibitor Prevents Lethal Acute Graft-Versus-Host Disease in Mice

Koichi Hattori, T Hirano, Chifuyu Ushiyama, +10

Blood