Robert A. Mantei

Discovery of <i>N</i>-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

Keith F. McDaniel, Le Wang, Todd Soltwedel et al. · Journal of Medicinal Chemistry · 2017 · 133 citations · Full text

2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ET_A Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722

Martin Winn, Thomas W von Geldern, Terry J. Opgenorth et al. · Journal of Medicinal Chemistry · 1996 · 110 citations · Full text

Combinatorial Chemistry, Molecular Pharmacology, Medicinal Chemistry +12

Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

Lisa Hasvold, Weibo Wang, Stephen L. Gwaltney et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 73 citations · Full text

Medicinal Chemistry, Pyridone-containing Farnesyltransferase Inhibitors, Medicine +5

Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases

Michael R. Michaelides, Arthur F. Kluge, Michael A. Patane et al. · ACS Medicinal Chemistry Letters · 2017 · 72 citations · Full text

Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of <i>N</i>-Phenyl Amide 6-Substitution

Michael Wendt, Todd W. Rockway, Andrew Geyer et al. · Journal of Medicinal Chemistry · 2003 · 66 citations · Full text