Michael Wendt

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker et al. · Nature · 2005 · 3.4K citations

Tumor Biology, Bcl-2 Family Proteins, Medicine +9

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Andrew J. Souers, Erwin R. Boghaert, Scott Ackler et al. · Nature Medicine · 2013 · 2.9K citations

Thrombopoiesis, Thrombosis, Hematological Malignancy +11

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Darren C. Phillips, Michael J. Mitten, Erwin R. Boghaert et al. · Science Translational Medicine · 2015 · 530 citations · Full text

Cancer Therapy, Chemoprevention Strategy, Bcl-2/bcl-xl/bcl-w Inhibitor Abt-263 +20

Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

Milan Bruncko, Thorsten Oost, Barbara Belli et al. · Journal of Medicinal Chemistry · 2007 · 294 citations · Full text

Immunology, Pharmacotherapy, Pharmaceutical Chemistry +19

Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins

Cheol‐Min Park, Milan Bruncko, Jessica Adickes et al. · Journal of Medicinal Chemistry · 2008 · 291 citations · Full text