Concepedia

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker, Robert C. Armstrong, David J. Augeri, Barbara Belli, Milan Bruncko, Thomas L. Deckwerth, Jürgen Dinges, Philip J. Hajduk,

Nature · 2005 · 3.4K citations · 21 references

DOI

Concepts

References

21

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

Michael C. Wei, Wei‐Xing Zong, Emily H. Cheng et al. · Science · 2001 · 3.9K citations · Full text

, , +17

Discovering High-Affinity Ligands for Proteins: SAR by NMR

Suzanne B. Shuker, Philip J. Hajduk, Robert Meadows et al. · Science · 1996 · 2K citations

, , +14

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

Yoshihide Tsujimoto, L R Finger, Jorge J. Yunis et al. · Science · 1984 · 1.8K citations

, , +17

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Anthony Letai, Michael C. Bassik, Loren D. Walensky et al. · Cancer Cell · 2002 · 1.6K citations · Full text

, , +16

Structure of Bcl-x <sub>L</sub> -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

Michael Sattler, Heng Liang, David G. Nettesheim et al. · Science · 1997 · 1.5K citations

, , +17