Loren D. Walensky

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Anthony Letai, Michael C. Bassik, Loren D. Walensky et al. · Cancer Cell · 2002 · 1.6K citations · Full text

Mitochondrial Apoptosis, Mitochondrial Function, Apoptosis +9

Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

Loren D. Walensky, Andrew L. Kung, Iris Escher et al. · Science · 2004 · 1.3K citations · Full text

Hydrocarbon-stapled Bh3 Helix, Protein Function, Hydrocarbon Stapling +12

BAX activation is initiated at a novel interaction site

Evripidis Gavathiotis, Motoshi Suzuki, Marguerite L. Davis et al. · Nature · 2008 · 680 citations · Full text

Signal Transduction, Interaction Technique, Mechanism Of Action +5

Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide

Federico Bernal, Andrew Tyler, Stanley J. Korsmeyer et al. · Journal of the American Chemical Society · 2007 · 553 citations

Chemoprevention Strategy, Apoptosis, Molecular Biology +18

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

Jennifer A. Perry, Adam Kieżun, Peter Tonzi et al. · Proceedings of the National Academy of Sciences · 2014 · 484 citations · Full text